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Characteristics of the invasive lobular carcinoma with extracellular mucin . The tumor cells revealed strong cytoplasmic MUC1 staining (top left, immunohistochemistry, ×200), but were negative for MUC2, MUC4, MUC5AC and MUC6 (images not shown). The tumor cells were positive for ER (top right, ×400), negative for PR (image not shown), and positive for <t>HER-2/neu</t> with 3+ staining (bottom left, ×400). FISH study confirmed the amplification of HER-2 gene (bottom right, ×1,000).
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Characteristics of the invasive lobular carcinoma with extracellular mucin . The tumor cells revealed strong cytoplasmic MUC1 staining (top left, immunohistochemistry, ×200), but were negative for MUC2, MUC4, MUC5AC and MUC6 (images not shown). The tumor cells were positive for ER (top right, ×400), negative for PR (image not shown), and positive for <t>HER-2/neu</t> with 3+ staining (bottom left, ×400). FISH study confirmed the amplification of HER-2 gene (bottom right, ×1,000).
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Characteristics of the invasive lobular carcinoma with extracellular mucin . The tumor cells revealed strong cytoplasmic MUC1 staining (top left, immunohistochemistry, ×200), but were negative for MUC2, MUC4, MUC5AC and MUC6 (images not shown). The tumor cells were positive for ER (top right, ×400), negative for PR (image not shown), and positive for HER-2/neu with 3+ staining (bottom left, ×400). FISH study confirmed the amplification of HER-2 gene (bottom right, ×1,000).

Journal: Diagnostic Pathology

Article Title: Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies

doi: 10.1186/1746-1596-5-36

Figure Lengend Snippet: Characteristics of the invasive lobular carcinoma with extracellular mucin . The tumor cells revealed strong cytoplasmic MUC1 staining (top left, immunohistochemistry, ×200), but were negative for MUC2, MUC4, MUC5AC and MUC6 (images not shown). The tumor cells were positive for ER (top right, ×400), negative for PR (image not shown), and positive for HER-2/neu with 3+ staining (bottom left, ×400). FISH study confirmed the amplification of HER-2 gene (bottom right, ×1,000).

Article Snippet: Fluorescence in situ hybridization (FISH) analysis of HER2 gene was performed on a formalin-fixed block using PathVysion dual color HER-2 DNA Probe Kit (Vysis, Downers Grove, IL).

Techniques: Staining, Immunohistochemistry, Amplification